Analysis of the transcriptional response of Candida parapsilosis following exposure to farnesol

We used the results of a genome sequence survey to design and manufacture partial genomic microarrays that were applied to determining the transcriptional response of C. parapsilosis to the presence of exogenous farnesol. Keywords: drug response, farnesol, Transcriptional profiling was performed following exposure to 50 microM of farnesol compare to the control experiment (no treatment). Six independent experiment comparisons (including 3 dye swaps) were performed.

本研究借助基因组序列调查（genome sequence survey）的结果，设计并制备了部分基因组微阵列（partial genomic microarrays），用于检测近平滑假丝酵母（C. parapsilosis）对外源性法尼醇（exogenous farnesol）的转录响应。
关键词：药物响应（drug response）、法尼醇（farnesol）
本研究针对暴露于50微摩尔法尼醇的实验组与未处理的对照组开展转录谱分析（Transcriptional profiling），共完成6组独立实验对照，其中包含3次染料交换（dye swaps）实验。