Dataset (NVP Index)

Systemic immune inflammation index, systemic inflammatory response index and pan-immune inflammation value in predicting nausea and vomiting in pregnancy and the need for hospitalization Abstract Objective To investigate the role of the systemic immune-inflammation index (SII), systemic inflammatory response index (SIRI) and pan-immune inflammation value (PIV) in predicting nausea and vomiting in pregnancy (NVP). Study Design Women diagnosed and treated for NVP at a large tertiary hospital between 2016 and 2021 were retrospectively analyzed. After applying the inclusion criteria, a total of 278 eligible patients with NVP and 278 gestational age-matched healthy pregnant women were included. Patients with NVP were divided into mild (n=58), moderate (n=140) and severe NVP (n=80). Patients with moderate and/or severe NVP who were at high risk for hospitalization were pooled and assigned to an inpatient treatment group. The data from the first trimester of the groups were then compared. Results SII and PIV were significantly higher in the NVP group than in the control group, while SII, SIRI and PIV were significantly higher in the inpatient treatment group than in the mild NVP group. The comparison of overall performance in predicting the development of NVP showed that SII was better than PIV (p<0.001), while there was no significant superiority between SII, SIRI and PIV in predicting the need for inpatient treatment. An SII with a cut-off value of >1207x103/µL (47.48% sensitivity, 82.01% specificity) had the highest discriminatory power for predicting NVP. Conclusion Our results suggest an association between high SII and PIV and an increased risk of future NVP. These markers can be used as a first-trimester screening test to improve treatment planning of pregnancies at high risk of HG.

全身免疫炎症指数、全身炎症反应指数及泛免疫炎症值预测妊娠恶心呕吐与住院需求的价值
摘要
目的 探讨全身免疫炎症指数（systemic immune-inflammation index, SII）、全身炎症反应指数（systemic inflammatory response index, SIRI）及泛免疫炎症值（pan-immune inflammation value, PIV）对妊娠恶心呕吐（nausea and vomiting in pregnancy, NVP）的预测价值。
研究设计 选取2016年至2021年于某大型三级医院就诊并接受治疗的NVP患者开展回顾性分析。经纳入标准筛选后，最终纳入278例符合条件的NVP患者，以及278例孕周匹配的健康妊娠女性作为对照。将NVP患者分为轻度组（n=58）、中度组（n=140）与重度组（n=80）；将存在住院高风险的中度及/或重度NVP患者合并为住院治疗组。随后对各组受试者妊娠早期的相关数据进行比较分析。
结果 NVP组的SII与PIV水平均显著高于对照组；住院治疗组的SII、SIRI及PIV水平均显著高于轻度NVP组。在预测NVP发生的整体效能对比中，SII的表现优于PIV（p<0.001）；而在预测住院治疗需求方面，SII、SIRI与PIV的效能无显著差异。当SII的截断值设定为＞1207×10³/µL时，其灵敏度为47.48%、特异度为82.01%，对NVP的预测鉴别效能最高。
结论 本研究结果显示，较高的SII与PIV水平与未来发生NVP的风险升高存在关联。上述指标可作为妊娠早期筛查指标，用于优化妊娠剧吐（hyperemesis gravidarum, HG）高风险孕妇的诊疗方案。