Association between inflammatory cytokines and psychosomatic syndromes in patients with mood disorders: a cross-sectional study

This study explored the relationship between inflammation and psychosomatic symptoms in major and bipolar depression. Elevated levels of pro-inflammatory cytokines, particularly IL-6 and TNF-α, were significantly associated with psychosomatic syndromes, especially persistent somatization (PS). These associations remained significant even after adjusting for depressive symptoms and other confounding factors. No moderating effect of sex was found. The findings suggest that inflammation contributes more to psychosomatic symptoms than to mood symptoms alone, highlighting its potential as a clinical and therapeutic target in mood disorders.

本研究探讨了炎症与重度抑郁症及双相情感障碍中心身症状的关系。促炎细胞因子水平升高（尤其是IL-6与TNF-α）与心身综合征显著相关，其中持续性躯体化（PS）的关联最为突出。即使在调整抑郁症状及其他混杂因素后，这些关联仍具有统计学意义。研究未发现性别存在调节效应。结果表明，炎症对心身症状的影响大于单纯对情绪症状的作用，凸显了其作为心境障碍临床干预及治疗靶点的潜在价值。