Aminophylline induces two types of arrhythmic events in human pluripotent stem cell-derived cardiomyocytes - Dataset

This dataset contains raw and processed AFM data of measuring the contractility activity of 3D clusters of cardiomyocytes (Embryoid bodies) after administrating bronchodilator Aminophylline in increasing concentration. Dataset is coupled with journal article:''Aminophylline induces two types of arrhythmic events in human pluripotent stem cell-derived cardiomyocytes'' published in Frontiers in Pharmacology (https://doi.org/10.3389/fphar.2021.789730).

Some data from the original dataset was also used in the article "Integrated analysis of Cardiomyocyte Mechanical and Electrical Function: Open Source Scripts for AFM and MEA Data Characterization". Additional data used in this article (Electromechanical coupling data, artificial data) was added in version 2.0 (see changelog).

Changelog:

2.0

-Addition of results of HL-1 cells measurement including a multielectrode array (MEA) and Calcium sparklings measurements.-Removing of Barium measurements data

3.0

-Addition of data used used in the article "Integrated analysis of Cardiomyocyte Mechanical and Electrical Function: Open Source Scripts for AFM and MEA Data Characterization".

本数据集收录了以递增浓度给予支气管扩张剂氨茶碱（Aminophylline）后，心肌细胞（胚状体，Embryoid bodies）三维集群收缩活性的原始与经处理的原子力显微镜（Atomic Force Microscopy, AFM）数据。本数据集配套关联发表于《药理学前沿》（Frontiers in Pharmacology）的期刊论文《氨茶碱在人多能干细胞源性心肌细胞中诱发两类心律失常事件》，论文原文标题为Aminophylline induces two types of arrhythmic events in human pluripotent stem cell-derived cardiomyocytes，对应DOI：https://doi.org/10.3389/fphar.2021.789730。

本数据集的部分原始数据还曾被用于另一篇论文《心肌细胞机械与电功能整合分析：用于原子力显微镜与微电极阵列数据表征的开源脚本》，该论文原文标题为Integrated analysis of Cardiomyocyte Mechanical and Electrical Function: Open Source Scripts for AFM and MEA Data Characterization。该论文中使用的额外数据（电机械耦合数据、人工生成数据）已在2.0版本中加入，详见变更日志。

变更日志：
2.0版本
- 新增HL-1细胞的测量结果，涵盖微电极阵列（Multielectrode Array, MEA）与钙火花（Calcium sparklings）测量数据。
- 移除了钡剂测量相关数据集。
3.0版本
- 新增了论文《心肌细胞机械与电功能整合分析：用于原子力显微镜与微电极阵列数据表征的开源脚本》中使用的数据集。