New Zirconium-Mediated Approach Toward Regio- and Stereocontrolled Synthesis of <i>trans</i>-Enediynes

The coupling reactions of α-alkynylated zirconacyclopentene based on 1,4-bis(trimethylsilyl)-1,3-butadiyne with unsaturated compounds are
described, which provide an efficient, regio- and stereocontrollable synthesis of trans-enediynes in a one-pot procedure. An interesting alkynyl
group shift from α- to β-position of the zirconium center during the reaction was observed, which was accountable for the novel transformations
to trans-enediynes.

本数据集记述了基于1,4-双(三甲基硅基)-1,3-丁二炔的α-炔基化锆杂环戊烯（α-alkynylated zirconacyclopentene）与不饱和化合物的偶联反应体系。该体系可通过一锅法实现反式烯二炔（trans-enediynes）的高效、区域与立体可控合成。反应过程中观测到有趣的炔基从锆中心的α-位向β-位迁移现象，该迁移过程正是生成反式烯二炔类产物的新型转化路径的关键成因。