Mus musculus Transcriptome or Gene expression

This study aims to elucidate the molecular mechanisms by which extracellular vesicles regulate the progression of ovarian cancer. Mouse ovarian cancer cells (ID8) were treated with extracellular vesicles, and RNA sequencing was performed to identify differentially expressed genes and significantly enriched signaling pathways, including the ferroptosis pathway. The resulting transcriptomic data provide important insights into the metabolic regulation of tumor progression and may help reveal the potential therapeutic role of extracellular vesicles in ovarian cancer.

本研究旨在阐明细胞外囊泡（extracellular vesicles）调控卵巢癌进展的分子机制。本研究使用细胞外囊泡处理小鼠卵巢癌细胞（ID8），通过RNA测序鉴定差异表达基因与显著富集的信号通路，其中包含铁死亡（ferroptosis）通路。本研究获得的转录组数据为肿瘤进展的代谢调控机制提供了重要见解，或有助于揭示细胞外囊泡在卵巢癌治疗中的潜在价值。