PLY and MDSCs

Our data indicated that the mitigation of EAE with pseudolycorine chloride comes from its ability to target a range of anti-inflammatory pathways, including inhibition of the differentiation of M-MDSCs and proliferation of MDSCs both in vitro and in vivo, decrease in inflammatory infiltration and demyelination in the spinal cord, and preventing the migration of MDSCs and related Th17 cells to the CNS.

本研究数据表明，氯化伪石蒜碱（pseudolycorine chloride）对实验性自身免疫性脑脊髓炎（EAE）的缓解作用，源于其能够靶向多条抗炎信号通路，具体包括：在体外（in vitro）与体内（in vivo）均抑制单核细胞样髓源抑制细胞（M-MDSCs）的分化以及髓源抑制细胞（MDSCs）的增殖，减轻脊髓组织的炎性浸润与脱髓鞘病变，同时阻断髓源抑制细胞及相关辅助性T细胞17（Th17 cells）向中枢神经系统（CNS）的迁移。