Gene expression in murine regulatory T cells in chronic lymphocytic leukemia

mRNA profiles were generated by 3'-sequencing, in triplicate from different regulatory T cells populations of 8-week-old Foxp3-EGFP mice, healthy (Ctrl) or leukemia-bearing (TCL1) . mRNA profiles of sorted Treg from Foxp3-EGFP mice (Ctrl) and with leukemia (subsets A CD44low CD69+ LAG3high and subset B CD44high CD69+ LAG3low)

本数据集的mRNA表达谱通过3'端测序（3'-sequencing）生成，样本取自8周龄健康（对照组，Ctrl）或携白血病（TCL1组）的叉头框蛋白P3-增强绿色荧光蛋白（Foxp3-EGFP）小鼠的不同调节性T细胞（regulatory T cells）亚群，且设置三次生物学重复。此外，本数据集还包含分选自健康Foxp3-EGFP小鼠（Ctrl组）以及携白血病Foxp3-EGFP小鼠的调节性T细胞（Treg）的mRNA表达谱；其中白血病组调节性T细胞分为两个亚群：亚群A为CD44low CD69+ LAG3high，亚群B为CD44high CD69+ LAG3low。