Support data for "Development of a bimetallic zeolite for caries management"

Dental caries is a globally prevalent oral disease. It is caused by cariogenic microorganisms, a cariogenic diet, susceptible tooth surfaces and time. Caries begins when cariogenic bacteria accumulate on tooth surfaces and metabolize sugars to produce lactic acid, which leads to tooth demineralization. Demineralization is the process of removing mineral ions (calcium and phosphate) from the hydroxyapatite crystals of the tooth's hard tissue. Therefore, dental materials that inhibit the growth of cariogenic microorganisms and stabilize the release of calcium ions over time are thought to have the potential to control dental caries. In Chapter 2 of my study, I provide a narrative review of the applications of zeolites and zeolite imidazolate frameworks (ZIFs) in various fields of dentistry such as restorative dentistry, endodontics, prosthodontics, implantology, periodontics, orthodontics, and oral surgery. Based on the great potential of zeolites in dentistry, in Chapter 3 of the study, we synthesized a novel zeolite focused on caries management. In Chapter 4 of the study, we developed a novel glass ionomer cement for caries management by adding calcium-silver zeolite to GIC.

龋齿是全球范围内普遍存在的口腔疾病。其成因包括致龋微生物、致龋饮食、易感牙面以及时间因素。龋齿的形成始于致龋细菌在牙面上的累积及其对糖分的代谢，产生乳酸，进而导致牙齿脱矿。脱矿是指从牙齿硬组织的羟基磷灰石晶体中移除矿物离子（钙和磷酸盐）的过程。因此，那些能够抑制致龋微生物生长并稳定钙离子随时间释放的口腔材料，被认为具有控制龋齿的潜力。在我研究的第二章中，我提供了一篇关于沸石及其咪唑类框架（ZIFs）在口腔医学各个领域应用（如修复牙科、根管治疗、牙修复学、种植牙学、牙周病学、正畸学和口腔外科）的综述。鉴于沸石在口腔医学领域的巨大潜力，本研究第三章中，我们合成了一种针对龋齿管理的创新沸石。在研究的第四章中，我们通过添加钙银沸石到玻璃离子粘固剂（GIC）中，开发了一种新型的玻璃离子粘固剂用于龋齿管理。