Skeletal muscle mRNA and phosphorylation levels.

TNFα converting enzyme (TACE), toll-like receptor 4 (TLR4), interleukin (IL)-6, IL-10, macrophage specific marker (F4/80) mRNA as well as p38Thr180, Tyr182 phosphorylation (p38-p) in quadriceps muscle from whole body PGC-1α knockout (KO), muscle specific PGC-1α KO (MKO) and muscle specific PGC-1α overexpression (TG) mice and their respective littermate wild type (WT) mice, 2 hours after injection with either saline (Sal) as control or lipopolysaccharide (LPS). Values are presented as means ± S.E. with n = 10 in each group.*: Significantly different from Sal within given genotype, p#: Significantly different from WT within given treatment, p

本数据集检测了全身过氧化物酶体增殖物激活受体γ辅激活因子1α（PGC-1α）基因敲除（KO）、肌肉特异性PGC-1α基因敲除（MKO）以及肌肉特异性PGC-1α过表达（TG）小鼠与其相应同窝野生型（WT）小鼠的股四头肌中，肿瘤坏死因子α转化酶（TACE）、Toll样受体4（TLR4）、白细胞介素-6（IL-6）、白细胞介素10（IL-10）、巨噬细胞特异性标志物（F4/80）的信使核糖核酸（mRNA），以及p38苏氨酸180、酪氨酸182位点磷酸化形式（p38-p）的表达水平。所有小鼠分别经生理盐水（Sal，作为对照）或脂多糖（LPS）注射，于2小时后采集股四头肌组织。所有数值以平均值±标准误（S.E.）表示，每组样本量n=10。*：同基因型下与Sal组存在显著差异；p#：同处理方式下与WT组存在显著差异；p