Postantibiotic Effects of Gatifloxacin against Gram-Positive and -Negative Organisms

Gatifloxacin pneumococcal, staphylococcal and enterococcal postantibiotic effects (PAEs) were 0.5 to 4.0 h, respectively. For Escherichia coli and Pseudomonas aeruginosa, PAEs were 2.2 to 4.8 h. Pneumococcal, staphylococcal, and enterococcal postantibiotic sub-MIC effects (PA-SMEs) (four times the MICs) were 3.7 to 8.6, 2.3 to 3.8, and 1.6 h, respectively, and E. coli and P. aeruginosa PA-SMEs were ≥9.6 and 4.4 h, respectively.

加替沙星对肺炎链球菌、葡萄球菌及肠球菌的抗生素后效应（postantibiotic effects, PAEs）分别为0.5~4.0小时。针对大肠埃希菌与铜绿假单胞菌，其抗生素后效应时长为2.2~4.8小时。肺炎链球菌、葡萄球菌及肠球菌的抗生素后亚抑菌浓度效应（postantibiotic sub-MIC effects, PA-SMEs，此处亚抑菌浓度为4倍最低抑菌浓度）分别为3.7~8.6、2.3~3.8及1.6小时；大肠埃希菌与铜绿假单胞菌的该效应时长则分别≥9.6小时与4.4小时。