MSCs rescue lethally irradiated mice by differentiation-independent mechanisms. Mus musculus

Overall survival after irradiation was compared between HSC after single transplantation of MSC. Transplanted MSC did not differentiate into HSC, but salvaged endogeneous hematopoiesis. Overall design: BM, HSC and MSC were isolated from bone marrow 7 months after transplantation with MSCs.

本研究对比了经间充质干细胞（Mesenchymal Stem Cell, MSC）单次移植后的造血干细胞（Hematopoietic Stem Cell, HSC）的辐照后总生存期。移植的间充质干细胞并未分化为造血干细胞，而是挽救了内源性造血功能。总体实验设计：在接受间充质干细胞移植7个月后，从骨髓（Bone Marrow, BM）中分离得到骨髓（BM）、造血干细胞（HSC）与间充质干细胞（MSC）。