HVN1917 Rua Metadata Record - Tuhauora Rua: impact of different kawakawa dosing conditions on markers of metabolic health and inflammation in healthy human volunteers

This metadata record and it's attached files make statements about the kinds of data collected as part of this research, and set out policies for governance of that data, now and in the future.<b>Description:</b> Kawakawa (Piper excelsum) is endemic to Aotearoa, New Zealand, and, as a taonga, is of great cultural importance to Maori. Kawakawa is used extensively in rongoa Maori (traditional Maori healing). The pharmacology of kawakawa is complex, with studies reporting kawakawa to contain several biologically active compounds that influence inflammation and related pathways. For example, myristicin inhibits the production of several pro-inflammatory cytokines, such as NO, IL-6 and IL-10, in mouse macrophages and THP-1 monocytes. Elemicin, another aromatic compound in kawakawa, is known to play a role in inhibiting IL-6. We hypothesize that the consumption of kawakawa would impact the inflammatory pathways by enhancing anti-inflammatory effects. However, several confounding variables, such as individualized differences in kawakawa tea preparation and doses and variability in the bioavailability of the active kawakawa constituents, could also alter the anti-inflammatory effects. Therefore, controlled human kawakawa trials are necessary to evaluate the effects of different doses of kawakawa consumption on inflammatory markers. To test our hypothesis, this study aims to quantify the effects of different kawakawa doses on inflammatory markers in healthy human volunteers.

本元数据记录及其附属文件阐明了本研究中采集的各类数据类型，并明确了当前及未来该数据的管理政策。数据描述：卡瓦卡瓦（Kawakawa，学名Piper excelsum）是新西兰奥特亚罗瓦（Aotearoa）的特有物种，作为塔翁加（taonga），对毛利族具有极高的文化重要性。卡瓦卡瓦被广泛应用于毛利传统医药（rongoa Maori）中。卡瓦卡瓦的药理学特性较为复杂，现有研究显示其含有多种可调控炎症及相关信号通路的生物活性化合物。例如，肉豆蔻醚（myristicin）可在小鼠巨噬细胞与THP-1单核细胞中抑制多种促炎细胞因子的生成，如一氧化氮（NO）、白细胞介素-6（IL-6）及白细胞介素-10（IL-10）。榄香素（Elemicin）作为卡瓦卡瓦中的另一芳香类化合物，已被证实可抑制IL-6的生成。本研究假设，摄入卡瓦卡瓦可通过增强抗炎效应来调控炎症通路。然而，多项混杂变量可能会影响其抗炎效应，例如卡瓦卡瓦茶饮制备方式与服用剂量的个体差异，以及活性成分生物利用度的波动。因此，有必要开展人体对照试验，以评估不同剂量的卡瓦卡瓦摄入对炎症标志物的影响。为验证本研究假设，本研究旨在量化不同剂量的卡瓦卡瓦摄入对健康人体志愿者体内炎症标志物的影响。