Synthesis of 2,4,6-Trisubstituted Chiral Piperidines and (−)-Dendroprimine by One-Pot Asymmetric Azaelectrocyclization Protocol

Stereocontrolled synthesis of 2,4,6-trisubstituted piperidine diastereomers has been realized from common intermediates, obtained by a one-pot azaelectrocyclization protocol. Based on the method, the asymmetric synthesis of an indolizidine alkaloid, (−)-dendroprimine, was achieved.

通过一锅法氮杂电环化（azaelectrocyclization）反应策略制备得到常见中间体，并以此为原料成功实现了2,4,6-三取代哌啶非对映异构体的立体可控合成。基于该方法，完成了吲哚里西啶生物碱(−)-dendroprimine的不对称合成。