Mus musculus Transcriptome or Gene expression

Constitutive Speg-knockout mice die in utero. To overcome the perinatal mortality of Speg-knockout mice, we generated a conditional Speg-CKO mouse model. The conditional Speg-CKO mice were bred with striated muscle-specific cre mice, and the resulting Speg-CKO litters had a delay in Speg excision.

组成型Speg基因敲除小鼠会在宫内死亡。为解决Speg基因敲除小鼠的围产期致死问题，我们构建了条件性Speg-CKO（Conditional Knockout，CKO）小鼠模型。将该条件性Speg-CKO小鼠与横纹肌特异性Cre重组酶小鼠进行杂交，所得的Speg-CKO同窝仔鼠的Speg基因切除过程存在延迟。