Data from: Ovarian hormone deficiency enhances wood smoke-induced immune dysfunction via transcriptomic and metabolic alterations

The data were generated from bone marrow immune cells of ovariectomized
(OVX) C57BL/6 mice exposed to either filtered air (FA) or wood smoke (WS)
to investigate how ovarian hormone deficiency modifies the immunotoxic
effects of acute air pollution exposure. The dataset includes raw
paired-end FASTQ files and filtered feature-barcode count matrices (.h5
format) for three biological replicates from each of the two experimental
groups (OVX-FA and OVX-WS). Please note that other data presented in the
manuscript, such as the ex vivo functional and metabolic assays on bone
marrow-derived macrophages (BMDMs), are not included in this deposit.
These data can be used to reproduce the transcriptomic analyses of bone
marrow immune composition, cell-type-specific differential gene
expression, and pathway enrichment results described in the manuscript.

本数据集取自暴露于过滤空气（filtered air, FA）或木烟（wood smoke, WS）的卵巢切除（ovariectomized, OVX）C57BL/6小鼠的骨髓免疫细胞，旨在探究卵巢激素缺乏对急性空气污染暴露免疫毒性效应的调控作用。数据集包含两个实验组（OVX-FA组与OVX-WS组）各3次生物学重复的原始双端FASTQ文件，以及经筛选的特征-条形码计数矩阵（.h5格式）。请注意，本研究手稿中提及的其他数据（如针对骨髓来源巨噬细胞（bone marrow-derived macrophages, BMDMs）的离体功能与代谢检测数据）未包含在本存档数据集内。本数据集可用于复现手稿中描述的骨髓免疫细胞组成、细胞类型特异性差异基因表达及通路富集结果的转录组分析。