UGT1A1 Sanger sequencing data from Tibetan and Han Chinese newborns

This dataset is related to the study “Analysis of UGT1A1 Polymorphisms and Clinical Risk Factors for Neonatal Jaundice in Tibetan Newborns: A Comparative Study with Han Newborns in China.” It includes raw sequencing chromatograms (.ab1 files), aligned sequences (.fasta files), and summary tables of genotypes and clinical data.Umbilical cord blood samples were collected from Tibetan and Han Chinese newborns at the Maternal and Child Health Hospital of Shannan City, Tibet, between January 2024 and April 2025. Genomic DNA was extracted and genotyped using Sanger sequencing for three UGT1A1 variants: c.211G>A, the (TA)n promoter repeat, and c.-3279T>G.Clinical parameters such as birth weight, gestational age, mode of delivery, and transcutaneous bilirubin levels were recorded. The study was approved by the Ethics Committee of Yangtze University, and written informed consent was obtained from the parents of all participants.This dataset supports reproducibility and further research into the genetic and environmental risk factors of neonatal jaundice in high-altitude populations.

本数据集关联的研究为《藏族新生儿UGT1A1基因多态性与临床危险因素分析：与中国汉族新生儿的对比研究》。数据集包含原始测序色谱图（.ab1文件）、比对序列文件（.fasta文件）以及基因型与临床数据汇总表。
2024年1月至2025年4月期间，研究团队于西藏山南市妇幼保健院采集藏族与汉族新生儿的脐血样本。研究人员提取基因组DNA，并通过桑格测序（Sanger sequencing）对3个UGT1A1基因变异位点——c.211G>A、(TA)n启动子重复序列以及c.-3279T>G——完成基因分型。
研究同时记录了新生儿的出生体重、胎龄、分娩方式及经皮胆红素水平等临床参数。本研究已通过长江大学伦理委员会审查，并获得所有受试者父母签署的书面知情同意书。
本数据集可为高原人群新生儿黄疸的遗传与环境危险因素相关研究的可重复性验证及后续拓展研究提供数据支撑。