In Vitro Activity of a New Polyene, SPA-S-843, against Yeasts

The in vitro activity of a new water-soluble polyene, SPA-S-843, was evaluated against 116 strains of Candida, Cryptococcus, and Saccharomyces spp. and compared with that of amphotericin B. SPA-S-843 demonstrated better inhibitory activity against all of the yeasts examined and better fungicidal activity against Candida albicans, Candida glabrata, Candida krusei, and Candida tropicalis than did amphotericin B.

本研究评估了新型水溶性多烯类化合物SPA-S-843对116株假丝酵母菌属（Candida）、隐球菌属（Cryptococcus）及酵母菌属（Saccharomyces）菌株的体外抗菌活性，并与两性霉素B（amphotericin B）的活性进行了对比。结果显示，SPA-S-843对本次检测的所有酵母菌均表现出更优异的抑制活性，且相较于两性霉素B，对白假丝酵母菌（Candida albicans）、光滑假丝酵母菌（Candida glabrata）、克柔假丝酵母菌（Candida krusei）及热带假丝酵母菌（Candida tropicalis）具备更强的杀菌活性。