Depression among HF.

BackgroundHeart failure (HF) is a major clinical condition contributing to high morbidity, mortality, and healthcare burden. Depression is increasingly recognized as a nontraditional risk factor for HF. However, data on its prevalence among HF patients in Ethiopia remain limited. This study aimed to estimate the pooled prevalence of depression in Ethiopian HF patients.MethodsThe study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, using data abstraction from various electronic sources (PubMed, Web of Science, Google Scholar, Scopus, Science direct, African journal, and online University repositories studies). Studies reporting the prevalence of depression among heart failure patients found until 28th November, 2024 were included. Analysis was conducted using STATA version 17 software, with assessment of heterogeneity and publication bias. A random-effects meta-analysis model was used to estimate the pooled prevalence of depression.ResultsThis study revealing a pooled prevalence of depression among Heart failure patients in Ethiopia is 43.93%. Subgroup analyses based on region, type of institution, and sampling method showed different prevalence rates: the Southern Nations, Nationalities, and Peoples’ Region had the highest rate at 60.13%, while Addis Ababa had the lowest at 35.18%. In terms of study institution types, teaching hospitals reported the highest prevalence at 46.81%, whereas referral hospitals showed the lowest rate at 31.05%. When considering sampling techniques, consecutive sampling yielded the highest prevalence at 55.09%, compared to just 15.40% for systematic random sampling. The analysis indicated a publication bias (p = 0.003), which warranted the use of trim and fill methods.Conclusion and recommendationsThe rate of depression among heart failure patients in Ethiopia is notably high, highlighting the necessity for targeted interventions from the Ministry of Health to tackle this concern. It is essential to create multi-sectorial strategies that offer context-specific solutions, such as rehabilitation programs, to help reduce depression in heart failure patients. The review protocol was registered in PROSPERO ID: CRD42023405077.

背景 心力衰竭（Heart Failure, HF）是一类引发高发病率、高死亡率并造成沉重医疗负担的主要临床病症。抑郁症作为非传统危险因素，与心力衰竭的关联正日益受到学界认可。然而，目前埃塞俄比亚心力衰竭患者群体中抑郁症患病率的相关研究数据仍较为匮乏。本研究旨在估算埃塞俄比亚心力衰竭患者抑郁症的合并患病率。方法 本研究遵循系统评价与Meta分析首选报告条目（Preferred Reporting Items for Systematic Reviews and Meta-Analyses）指南，从多个电子数据源（PubMed、Web of Science、Google Scholar、Scopus、ScienceDirect、African Journal以及各大学在线学术知识库）提取研究数据。纳入截至2024年11月28日已发表的、报道心力衰竭患者抑郁症患病率的相关研究。数据分析采用STATA 17统计软件完成，同时对研究异质性与发表偏倚进行评估。本研究采用随机效应Meta分析模型估算抑郁症的合并患病率。结果 本研究结果显示，埃塞俄比亚心力衰竭患者的抑郁症合并患病率为43.93%。基于研究地域、医疗机构类型与抽样方法开展的亚组分析显示，不同分组的抑郁症患病率存在显著差异：南部民族、国家与人民地区患病率最高，达60.13%；亚的斯亚贝巴地区患病率最低，为35.18%。按医疗机构类型划分，教学医院报告的抑郁症患病率最高（46.81%），转诊医院患病率最低（31.05%）。在抽样方法层面，连续抽样法得到的抑郁症患病率最高（55.09%），而系统随机抽样法仅为15.40%。分析结果显示存在显著发表偏倚（p=0.003），因此需采用修剪与填充法进行校正。结论与建议 埃塞俄比亚心力衰竭患者的抑郁症患病率显著偏高，这凸显了埃塞俄比亚卫生部需针对该问题开展针对性干预的必要性。构建多部门协同策略、提供贴合本土实际的解决方案（如康复干预项目）以降低心力衰竭患者的抑郁症负担，实属必要之举。本综述方案已在PROSPERO平台注册，注册号为CRD42023405077。