Dataset from Genomic and Proteomic Network for Preterm Birth Research GWAS Case Control Study

A multi-center observational genome-wide association study (GWAS) designed to determine if there is a genetic predisposition to idiopathic preterm birth. Maternal and neonatal DNA from 743 spontaneous preterm births (20 to less than 34 weeks gestation), and 752 controls (39 to less than 42 weeks gestation) were analyzed. GWAS, phenotype, and clinical data are available in dbGaP. Cases were 1:1 matched with controls according to race and ethnicity, maternal age, and parity. Biospecimens are available for request through DASH. Please navigate to Explore Biospecimens at the top of this page.

本研究为一项多中心观察性全基因组关联研究（genome-wide association study, GWAS），旨在明确特发性早产是否存在遗传易感性。本研究纳入743例妊娠20周至不足34周的自发性早产病例，以及752例妊娠39周至不足42周的对照个体，对其母体及新生儿的DNA样本进行分析。全基因组关联分析、表型及临床数据可在dbGaP数据库获取。研究按照种族与族裔、产妇年龄及产次，将病例与对照以1:1的比例进行匹配。生物样本可通过DASH申请获取，请前往本页面顶部的「探索生物样本」版块进行操作。