Metadata record for the manuscript: Ivermectin converts cold tumors hot and synergies with immune checkpoint blockade for treatment of breast cancer

<b>Summary</b> This metadata record provides details of the data supporting the claims of the related manuscript: “Ivermectin converts cold tumors hot and synergies with immune checkpoint blockade for treatment of breast cancer ”. The related study shows that treatment with the FDA-approved anti-parasitic drug ivermectin induces immunogenic cancer cell death (ICD) and robust T cell infiltration into breast tumours. Type of data: tumour size measurements, flow cytometry, histology Subject of data: 4T1 cell line, BALB/c (<i>Mus musculus</i>) <b>Data access</b> The flow cytometry data (fluorescence-activated cell sorting--FACS) are available upon request from the corresponding author. Other data generated as part of the related study are tumour size measurements and histology. These are available upon request from the corresponding author. <b>Corresponding author(s) for this study</b> Peter P. Lee, M.D., Dept. of Immuno-Oncology, City of Hope and Beckman Research Institute, Beckman Center, room 5117, 1500 East Duarte Road, Duarte, CA 91010. Email: [e-mail]. <br> <b>Study approval </b> All procedures were performed under approval from City of Hope’s Animal Care and Use Committee.

<b>概述</b> 本元数据记录详细记述了支撑相关研究论文"伊维菌素将冷肿瘤（cold tumors）转化为热肿瘤（hot tumors）并与免疫检查点阻断（immune checkpoint blockade）疗法协同治疗乳腺癌"结论的实验数据。本相关研究表明，经美国食品药品监督管理局（Food and Drug Administration, FDA）批准的抗寄生虫药物伊维菌素治疗，可诱导免疫原性癌细胞死亡（immunogenic cancer cell death, ICD），并促使大量T细胞浸润乳腺癌肿瘤组织。数据类型：肿瘤体积测量数据、流式细胞术数据、组织学数据<br>数据对象：4T1细胞系、BALB/c小鼠（小家鼠<i>Mus musculus</i>）<br><b>数据获取</b> 流式细胞术数据（荧光激活细胞分选术，fluorescence-activated cell sorting, FACS）需向通讯作者申请获取。本相关研究产生的其余数据包括肿瘤体积测量数据与组织学数据，同样需向通讯作者申请获取。<br><b>本研究通讯作者</b> Peter P. Lee，医学博士，希望之城与贝克曼研究所肿瘤免疫学部，贝克曼中心5117室，东杜阿尔特路1500号，杜阿尔特，加利福尼亚州91010。电子邮箱：[e-mail]。<br><b>研究伦理审批</b> 所有实验操作均经希望之城动物护理与使用委员会批准。