Polymorphism in the interleukin-10 gene is associated with overactive bladder phenotype associated with HTLV-1 infection

Abstract INTRODUCTION Human T-cell lymphotropic virus type 1 (HTLV-1)-associated inflammatory diseases are not well understood; however, their clinical manifestations may be influenced by the host genetic background. METHODS We genotyped 298 individuals with HTLV-1 and 380 controls for interleukin-10 (IL10) gene variants-rs3024496, rs1800871, rs1800896-and used logistic regression analysis to determine their association with clinical phenotypes. RESULTS No association with HTLV-1 infection was observed. However, allele A of rs1800896 (1082bp upstream) was associated with protection against neurological impairment, specifically overactive bladder (OR=0.447, 95% CI 0.28-0.70, p=0.001). CONCLUSIONS Our data suggests that IL10 regulation ameliorates neurological damage in HTLV-1 infections.

摘要

引言：人类T细胞嗜淋巴病毒1型（HTLV-1）相关炎症性疾病的致病机制尚未完全阐明，但其临床表现可能受宿主遗传背景影响。

方法：本研究对298名HTLV-1感染者及380名健康对照者的白细胞介素-10（IL10）基因的rs3024496、rs1800871、rs1800896三个变异位点进行基因分型，并采用logistic回归分析探讨其与临床表型的关联。

结果：未观察到上述变异位点与HTLV-1感染存在关联。但rs1800896（位于转录起始位点上游1082bp处）的A等位基因可对神经功能损害起到保护作用，尤其是针对膀胱过度活动症（OR=0.447, 95% CI 0.28-0.70, p=0.001）。

结论：本研究数据表明，IL10的调控可减轻HTLV-1感染引发的神经损伤。