Multi-omics HUVEC data of Tibetan and Han in hypoxic induction.

Tibetan's adaptation to high-altitude environment at the Qinghai-Tibetan plateau represents a remarkable case of natural selection during recent human evolution. We generated time series paired RNAseq, ATACseq and Hi-C data in Tibetan and Han Chinese's umbilical endothelial cells from normoxia to hypoxia condition. Our results provide a broad resource of genome-wide hypoxia regulatory network to characterize the effect of genetic variation in high-altitude adaptation, and indicates large-scale maps of variants need proper cell types to understand its act on gene regulation. Overall design: Time series paired RNAseq, ATACseq and Hi-C data in Tibetan and Han Chinese's umbilical endothelial cells from normoxia to hypoxia condition.

藏族人群在青藏高原（Qinghai-Tibetan Plateau）对高海拔环境的适应，是近期人类演化历程中自然选择的标志性案例。我们在藏族与汉族的脐内皮细胞中，生成了从常氧到低氧条件下的时序配对RNA测序（RNAseq）、转座酶可及性测序（ATACseq）及高通量染色体构象捕获（Hi-C）数据。本研究结果为全基因组范围的低氧调控网络提供了丰富的研究资源，以解析遗传变异在高海拔适应中的功能效应；同时表明，大规模遗传变异图谱需要依托合适的细胞类型，才能阐明其对基因调控的作用机制。整体实验设计：在藏族与汉族的脐内皮细胞中，生成从常氧到低氧条件下的时序配对RNAseq、ATACseq及Hi-C数据。