Expression Data from CD4-CD25+regulatory T cells of VAVcreKeapfl/fl mice

The transcription factor Nrf2 regulates oxidative stress responses. The specific role played by Nrf2 in regulatory T cells (Treg), the central regulators of immune homeostasis, is unclear. We used microarrays to detail the global programme of gene expression in CD4+CD25+ T cells of VAVcreKeapfl/fl mice Genome-wide transcriptome analyses for VAVcreKeapfl/fl and WT CD4+CD25+ T cells were performed in independent triplicates using Gene Chip® Mouse Gene 2.0 arrays

核因子E2相关因子2（Nrf2）可调控氧化应激反应。目前尚不明确Nrf2在作为免疫稳态核心调节因子的调节性T细胞（Treg）中所发挥的具体功能。本研究利用基因芯片，详细解析了VAVcreKeapfl/fl小鼠CD4+CD25+ T细胞的全局基因表达程序；并采用Gene Chip®小鼠基因2.0芯片阵列，对VAVcreKeapfl/fl与野生型（WT）CD4+CD25+ T细胞开展了独立三次重复的全转录组分析。