Long Lasting Difficulties Questionnaire (LLDQ)

The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic pathways leading to normal and abnormal growth, development and health. An important focus of Generation R is to identify early life determinants of common (mostly non-communicable) diseases in adulthood. Pregnant women living in the Rotterdam area, the Netherlands, were included between 2002 and 2006. After birth, the children and their parents have been followed in multiple assessment waves up until young adulthood.

R世代研究（Generation R Study）是一项基于人群的前瞻性队列研究，覆盖从胎儿期到成年期的全过程。该研究旨在识别影响正常与异常生长、发育及健康的早期环境与遗传通路。R世代研究的一个重要焦点是识别成年期常见疾病（主要为非传染性疾病，non-communicable diseases）的生命早期决定因素。2002年至2006年间，研究纳入了居住在荷兰鹿特丹地区的孕妇。孩子出生后，研究通过多轮评估对其及父母进行随访，直至他们进入青年期。