DNA methylation in skeletal muscle of patients with hypertension and diabetes undergoing coronary artery bypass grafting surgery. DNA methylation in skeletal muscle of patients with hypertension and diabetes undergoing coronary artery bypass grafting surgery

Patients with hypertension alone, hypertension plus controlled diabetes and hypertension plus uncontrolled diabetes, and control patients without these conditions underwent coronary artery bypass grafting surgery. Skeletal muscle biopsy specimens were taken at the beginning ('pre-operative') and at the end ('post-operative') of the surgery. Overall design: 4 patients per each of the 4 groups: control, hypertension only, hypertension plus controlled diabetes and hypertension plus uncontrolled diabetes. Each patient was sampled twice: before and after surgery.

针对仅罹患高血压、高血压合并受控糖尿病、高血压合并未受控糖尿病的患者，以及无上述病症的对照受试者，均接受冠状动脉旁路移植术（coronary artery bypass grafting surgery）。分别于手术开始前（术前，pre-operative）与手术结束后（术后，post-operative）采集骨骼肌活检标本（skeletal muscle biopsy specimens）。实验整体设计如下：共设置4组受试者，每组各纳入4名患者，分别为对照组、仅高血压组、高血压合并受控糖尿病组以及高血压合并未受控糖尿病组；每名患者均接受两次采样，采样时点分别为术前与术后。