Summary of the potential sorafenib biomarker genes identified using pathway fitness scores.

Column 1 identifies the meta-cluster as viewed in Fig 7. Column 2 list whether the pathway fitness score is positive (+) or negative (-). Column 3 lists the gene. Column 4 lists the differential gene expression comparing responders(R) to non-responders(N). Over expression in responders is indicated by a +/-, and vice versa for over expression in non-responders. Column 5 lists the putative MOAs.

第1列标注如图7所示的元簇（meta-cluster）。第2列列明通路适合度评分（pathway fitness score）的正负属性，即正（+）或负（-）。第3列列出对应基因。第4列列出应答者（R）与无应答者（N）间的差异基因表达（differential gene expression）情况：应答者的基因过表达以“+/-”标识，无应答者的基因过表达则反之。第5列列出推定的作用机制（Mechanism of Action, MOA）。