EGFRIndb: Epidermal Growth Factor Receptor Inhibitor Database

EGFRIndb is a specialized, literature-curated database focused on small synthetic molecular inhibitors of the Epidermal Growth Factor Receptor (EGFR) family. This resource centralizes experimental data on compounds targeting EGFR and its various isoforms, which are critical pharmacological targets due to their association with cancers such as lung and breast cancer.

Web Server: https://webs.iiitd.edu.in/raghava/egfrindb/

About the Database

The EGFR family consists of four trans-membrane protein isoforms: EGFR (ErbB1), ErbB2, ErbB3, and ErbB4. Aberrant activity, such as overexpression or mutation in these receptors, often leads to uncontrolled cell proliferation and cancer. EGFRIndb was developed to pool scattered biological activity data into a single platform to support drug discovery and decision-making.

Data Scope: Curated from PubMed and Google Scholar search results through December 2013.

Target Diversity: Includes inhibitors for EGFR, ErbB2, ErbB4, and clinically relevant mutants.

If you use EGFRIndb, please cite:

Inderjit S. Yadav, Harinder Singh, Mohd. Imran Khan, Ashok Chaudhury, G.P.S. Raghava, Subhash M. Agarwal, EGFRIndb: Epidermal Growth Factor Receptor Inhibitor Database, Anti-Cancer Agents in Medicinal Chemistry; Volume 14, Issue 7, Year 2014, .DOI: 10.2174/1871520614666140323203140

EGFRIndb 是一款经文献手工整理的专业数据库，聚焦于表皮生长因子受体（Epidermal Growth Factor Receptor, EGFR）家族的小分子合成抑制剂。该资源整合了靶向 EGFR 及其多种亚型的化合物实验数据——由于这类受体与肺癌、乳腺癌等多种癌症密切相关，它们是至关重要的药理学靶点。

Web 服务器：https://webs.iiitd.edu.in/raghava/egfrindb/

## 数据库简介
EGFR 家族包含四种跨膜蛋白亚型：EGFR（ErbB1）、ErbB2、ErbB3 与 ErbB4。当这类受体出现过表达或突变等异常激活情况时，通常会引发细胞增殖失控并诱发癌症。EGFRIndb 的开发初衷是将分散的生物活性数据整合至单一平台，以支持药物研发与决策制定工作。

### 数据范围
数据源自 PubMed 与 Google Scholar 的检索结果，收录截止至 2013 年 12 月。

### 靶点多样性
涵盖针对 EGFR、ErbB2、ErbB4 以及临床相关突变体的抑制剂。

若使用 EGFRIndb，请引用如下文献：
Inderjit S. Yadav、Harinder Singh、Mohd. Imran Khan、Ashok Chaudhury、G.P.S. Raghava、Subhash M. Agarwal，《EGFRIndb：表皮生长因子受体抑制剂数据库》，刊载于《Anti-Cancer Agents in Medicinal Chemistry》2014 年第 14 卷第 7 期，DOI: 10.2174/1871520614666140323203140