Sample images for human RhoGEF:RhoGAP RNAi screens in triple negative breast cancer.zip

Sample images for human RhoGEF/RhoGAP siGENOME and ONTARGETPlus siRNA screens on highly metastatic triple negative breast cancer cell line LM2, and its less metastatic parental cell line MDA-MB-231. Images shown are for genes which enrich for a particular shape or YAP/TAZ localisation/levels. Overlay of α -tubulin, polymerized F-actin, YAP and TAZ, and Hoechst stains. YAP/TAZ stain in red.

本数据集包含针对高转移性三阴性乳腺癌细胞系LM2及其低转移性亲本细胞系MDA-MB-231开展的人源Rho鸟苷酸交换因子（RhoGEF）/Rho GTP酶激活蛋白（RhoGAP）siGENOME与ONTARGETPlus小干扰RNA（siRNA）筛选的样本图像。所展示的图像对应富集特定细胞形态或YAP/TAZ定位与表达水平的基因，为α-微管蛋白、聚合态F-肌动蛋白、YAP/TAZ以及Hoechst染色的叠加成像结果，其中YAP/TAZ染色以红色呈现。