Proteomic profiling of capsaicin-induced relapse of chronic colitis

It has now been established that consumption of spicy food containing capsaicin is strongly associated with recurrence and worsening of symptoms in IBD.To uncover the potential signaling pathway involved in the capsaicin-induced relapse.To uncover the potential signaling pathway involved in the capsaicin-induced relapse,we performed proteomics of chronic colitis mice following capsaicin administration.Differential expression proteins which were tightly associated with inflammatory pathways have to be revealed.Differential expression proteins which were tightly associated with inflammatory pathways have to be revealed.The proteomic profile can help to identify the crucial pro-inflammatory factor implicated in the procedure of capsaicin-induced disease relapse.

目前已有研究证实，摄入含有辣椒素（capsaicin）的辛辣食物与炎症性肠病（Inflammatory Bowel Disease, IBD）患者的症状复发及病情加重存在显著关联。为揭示辣椒素诱导疾病复发所涉及的潜在信号通路，本研究对给予辣椒素处理的慢性结肠炎小鼠开展了蛋白质组学分析，并筛选出与炎症通路紧密相关的差异表达蛋白。该蛋白质组学图谱将有助于明确辣椒素诱导疾病复发过程中关键的促炎因子。