SOX2 Reprograms the Esophageal Squamous Carcinoma Epigenome and Induces Endogenous Retroviral Elements and dsRNA, Thereby Promoting ADAR1 Dependence [ChIP-Seq, ATAC-Seq]

We analyzed ChIP-seq, chromatin accessibility and RNA-seq across mouse esophageal squamous organoids and human esophageal squamous cell cancer ChIPseq and ATACseq analysis of esophageal squamous organoids and cancer cell lines

本研究针对小鼠食管鳞状类器官开展了染色质免疫共沉淀测序（ChIP-seq）、染色质开放性检测及RNA测序（RNA-seq）分析，并针对人类食管鳞状细胞癌相关的食管鳞状类器官与癌细胞系完成了染色质免疫共沉淀测序（ChIP-seq）与转座酶可及性测序（ATAC-seq）分析。