Membrane-Anchored Peptide Inhibits Human Immunodeficiency Virus Entry

Peptides derived from the heptad repeats of human immunodeficiency virus (HIV) gp41 envelope glycoprotein, such as T20, can efficiently inhibit HIV type 1 (HIV-1) entry. In this study, replication of HIV-1 was inhibited more than 100-fold in a T-helper cell line transduced with a retrovirus vector expressing membrane-anchored T20 on the cell surface. Inhibition was independent of coreceptor usage.

源自人类免疫缺陷病毒（human immunodeficiency virus, HIV）gp41包膜糖蛋白（gp41 envelope glycoprotein）七肽重复区的肽类物质（如T20），可高效抑制1型人类免疫缺陷病毒（human immunodeficiency virus type 1, HIV-1）的细胞入侵过程。本研究中，在经表达细胞表面膜锚定T20的逆转录病毒载体（retrovirus vector）转导的辅助T细胞系（T-helper cell line）内，HIV-1的复制被抑制超过100倍。该抑制作用与病毒的共受体利用特性无关。