CSF Analysis in HIV-1 Infected Subjects: Response to Antiretroviral Therapy

The purpose of this study is to provide a reference profile of small extracellular RNAs in body fluids. These samples were originally obtained in a study that had a different purpose. The purpose of the original study was to collect information on the changes in cerebrospinal fluid (CSF) related to HIV infection, including the viral burden (amount of virus) and the body responses of the infected individual, such as the number and types of lymphocytes in the CSF. In addition to looking at the number and types of lymphocytes in the CSF, this original study also examined the presence of markers of inflammation and other chemical changes, and the relationship of those changes to nervous system dysfunction in AIDS.]]>
For inclusion in the study, the control participants had to be 18 years or older and have documentation of negative serological test for HIV infection within 4 months and a history consistent with low risk for interim infection. All participants also needed to have 8 or more years of education and measured hemoglobin >10 mg/dg.]]>

本研究旨在为体液中的小型细胞外核糖核酸（small extracellular RNAs）建立参考图谱。本次研究使用的样本最初取自一项研究目标不同的前期研究。该前期研究的核心任务为收集与人类免疫缺陷病毒（HIV）感染相关的脑脊液（cerebrospinal fluid, CSF）变化数据，涵盖病毒载量（病毒数量）以及感染者的机体反应，例如脑脊液中淋巴细胞的数量与类型。除分析脑脊液淋巴细胞的数量与类型外，该前期研究还检测了炎症标志物及其他化学变化，并探究了此类变化与艾滋病患者神经系统功能障碍之间的关联。

本研究的纳入标准为：对照受试者需年满18周岁，且在4个月内的HIV血清学检测结果为阴性，同时具备与近期感染低风险史相符的背景；所有受试者均需接受8年及以上的教育，且血红蛋白检测值大于10 mg/dg。