Live Kidney Donor Study - Cross-Sectional and Historical Cohort Study (RELIVE-04)

The goal of this study is to determine the long-term risks of donor nephrectomy, compared to appropriate control subjects. This study built on information generated from RELIVE-01, a separate but related retrospective study. Through direct contact with previous living kidney donors this study examined the contribution of living kidney donation to the future development of hypertension, proteinuria, renal insufficiency or renal failure and anemia, the potential through these factors or others for increased cardiovascular risk for clinical events including myocardial infarction (MI), congestive heart failure (CHF), need for coronary artery bypass grafting (CABG) or percutaneous coronary angioplasty (PTCA) revascularization, and the impact of living kidney donation on quality of life (QOL) and financial status, compared to applicable control subjects and populations.

本研究旨在对比合适的对照受试者，明确供体肾切除术的长期风险。该研究基于RELIVE-01（一项独立但相关的回顾性研究）生成的信息展开。通过直接联系既往活体肾供体，本研究探讨了活体肾捐献对未来高血压、蛋白尿、肾功能不全或肾衰竭及贫血发生的影响；通过这些因素或其他因素增加心血管风险的可能性（涉及的临床事件包括心肌梗死（MI）、充血性心力衰竭（CHF）、冠状动脉旁路移植术（CABG）或经皮冠状动脉成形术（PTCA）血运重建需求）；以及对比适用的对照受试者和人群，分析活体肾捐献对生活质量（QOL）和经济状况的影响。