Additional file 1 of Daily rhythms in gene expression of the human parasite Schistosoma mansoni

Additional file 1: Supplementary tables 1-17. Table S1. All genes expressed in female Schistosoma mansoni samples over the two 24 hour periods including those with ~ 24 hr rhythmicity. Table S2. All genes expressed in male Schistosoma mansoni samples over the two 24 hour periods including those with ~ 24 hr rhythmicity. Table S3. All genes expressed in male head samples of Schistosoma mansoni over the two 24 hour periods including those with ~ 24 hr rhythmicity. Table S4. - Genes with differential expression over the two 24 hour periods in female Schistosoma mansoni samples including those with ~ 24 hr rhythmicity. Table S5. - Genes with differential expression over the two 24 hour periods in male Schistosoma mansoni samples including those with ~ 24 hr rhythmicity. Table S6. - Genes with differential expression over the two 24 hour periods in male head samples of Schistosoma mansoni including those with ~ 24 hr rhythmicity. Table S7. - Diel genes from the three datasets (i.e. all genes that are differentially expressed over 24 hours plus cycling with ~ 24 hr periodicity). Table S8. - Orthologs of Schistosoma mansoni diel genes. Table S9. - GO terms enriched in diel genes. Table S10. - Schistosoma mansoni adult cell types enriched in diel genes. Table S11. Diel genes involved in KEGG pathways. Table S12. Enrichment of Pfam families, InterPro domains, and KEGG pathways with diel genes. Table S13. Putative Schistosoma mansoni core and secondary circadian clock proteins. Table S14. Domain identifiers for main clock proteins were used to query WormBaseParaSite against the Schistosoma mansoni genome to identify putative orthologues. Table S15. -Animal circadian clock genes used in BLASTP searches and phylogenetic analyses to identify orthologues in Schistosoma mansoni. Table S16. One-to-one orthologs that show ~ 24 hr periodicity in Schistosoma mansoni and three other Metazoa; Drosophila melanogaster, Mus musculus and Cellana rota. Table S17. Diel genes with predicted drug inhibitors.

附加文件1：补充表1-17。表S1 曼氏血吸虫（Schistosoma mansoni）雌性样本在两个24小时周期内的全部表达基因，包含具有约24小时节律性的基因。表S2 曼氏血吸虫（Schistosoma mansoni）雄性样本在两个24小时周期内的全部表达基因，包含具有约24小时节律性的基因。表S3 曼氏血吸虫（Schistosoma mansoni）雄性头部样本在两个24小时周期内的全部表达基因，包含具有约24小时节律性的基因。表S4 曼氏血吸虫（Schistosoma mansoni）雌性样本中在两个24小时周期内存在差异表达的基因，包含具有约24小时节律性的基因。表S5 曼氏血吸虫（Schistosoma mansoni）雄性样本中在两个24小时周期内存在差异表达的基因，包含具有约24小时节律性的基因。表S6 曼氏血吸虫（Schistosoma mansoni）雄性头部样本中在两个24小时周期内存在差异表达的基因，包含具有约24小时节律性的基因。表S7 三个数据集的昼夜节律基因，即所有在24小时内存在差异表达且具有约24小时周期性的循环基因。表S8 曼氏血吸虫（Schistosoma mansoni）昼夜节律基因的同源基因。表S9 昼夜节律基因富集的基因本体（Gene Ontology，GO）术语。表S10 曼氏血吸虫（Schistosoma mansoni）成虫细胞类型中富集的昼夜节律基因。表S11 参与京都基因与基因组百科全书（Kyoto Encyclopedia of Genes and Genomes，KEGG）通路的昼夜节律基因。表S12 与昼夜节律基因相关的Pfam家族、InterPro结构域及KEGG通路的富集分析结果。表S13 曼氏血吸虫（Schistosoma mansoni）推定的核心及次级昼夜节律钟蛋白。表S14 利用主要节律钟蛋白的结构域标识符，通过WormBaseParaSite数据库比对曼氏血吸虫（Schistosoma mansoni）基因组以鉴定推定同源基因的相关信息。表S15 用于BLASTP（Basic Local Alignment Search Tool Protein）搜索及系统发育分析，以鉴定曼氏血吸虫（Schistosoma mansoni）同源基因的动物昼夜节律钟基因。表S16 一对一同源基因，这些基因在曼氏血吸虫（Schistosoma mansoni）及另外三种后生动物：黑腹果蝇（Drosophila melanogaster）、小家鼠（Mus musculus）和网纹帽贝（Cellana rota）中均表现出约24小时的周期性。表S17 预测存在药物抑制剂的昼夜节律基因。