The gut microbiome, frailty syndrome and comorbidities: a complex network in aging. The gut microbiome in frailty syndrome

Frailty is an aging-associated geriatric syndrome characterized by losing muscle mass and strength, reduced endurance, decreased physiological reserves, and cognitive impairment. It is estimated that between 4 and 27% of elders suffer from frailty, being more prone to experience a lower quality of life and a higher risk of death, hospitalization and institutionalization. During aging, the gut microbiota, the second genome, changes and could influence in the health status and trigger physiological disorders.

衰弱（frailty）是一种与衰老相关的老年综合征，以肌肉量与肌力流失、耐力下降、生理储备减少以及认知功能受损为特征。据估算，4%至27%的老年人受衰弱困扰，这类人群的生活质量更低，且死亡、住院以及机构养老的风险更高。在衰老过程中，作为人体第二基因组的肠道菌群（gut microbiota）会发生变化，可能影响机体健康状态并诱发生理功能紊乱。