Expression data from transplanted intestine bifor signs of rejection, and when their was signs of rejection

Acute cellular rejection (ACR) is the major cause of intestinal graft loss. Little is known about the genetic response occurring in small bowel transplantation (SBTx) during ACR. We report the case of a 44 year-old female with short gut syndrome following multiple surgeries for familial adenomatous polyposis that underwent living-related SBTx. We obtained for the first time a gene expression profile of the intestinal graft during ACR. Microarray analysis revealed increased transcript levels for genes that match identically to an IFN? signature reported for activated plasmacytoid dendritic cells and T-cell chemotaxis and cytolysis correlating with the diagnosis of ACR. Keywords: disease state analysis sam1, sam2, sam3 (without signs of rejection) sam4, sam5, sam6 (with signs and symptoms of rejection , histology showed increasing lymphocyte infiltration in the lamina propria and epithelium)

急性细胞排斥反应（Acute cellular rejection, ACR）是导致小肠移植物丢失的主要原因。目前对于急性细胞排斥反应发生时小肠移植（Small Bowel Transplantation, SBTx）中的基因应答机制仍所知有限。本研究报告1例因家族性腺瘤性息肉病接受多次手术后出现短肠综合征的44岁女性患者，该患者接受了亲属活体小肠移植。本研究首次获取了急性细胞排斥反应发生时小肠移植物的基因表达谱。基因芯片分析显示，与活化浆细胞样树突状细胞的干扰素特征、T细胞趋化及细胞溶解相匹配的基因转录水平显著升高，且与急性细胞排斥反应的诊断结果相符。关键词：疾病状态分析；sam1、sam2、sam3（无排斥迹象）；sam4、sam5、sam6（存在排斥相关体征与症状，组织病理学检查显示固有层及上皮内淋巴细胞浸润程度加重）