Procedural complications associated with percutaneous mitral balloon valvotomy: A systematic review

As Percutaneous mitral balloon valvotomy (PMBV) remains the keystone in treating mitral stenosis, we conducted this review to elucidate the cumulative frequency and predictors of complications following PMBV and their occurrence in various patient populations. We searched digital databases for relevant studies covering complications of PMBV and retrieved articles using the Medical Subject Heading (MeSH) keywords. A total of 37 articles (8 RCTs, 7 nonrandomized clinical trials, 22 observational studies) were selected for qualitative analysis. A total of 11,803 patients undergoing PMBV among 37 studies were included, with a mean success rate of 84.54%. The most common complication was mitral regurgitation (8.2%) followed by an atrial septal defect (2.4%). Other relevant complications like stroke, pericardial tamponade, rupture of mitral leaflets, and conduction abnormalities were present in <1% of the patients.

经皮二尖瓣球囊成形术（Percutaneous mitral balloon valvotomy, PMBV）仍是治疗二尖瓣狭窄的核心手段，本综述旨在阐明经皮二尖瓣球囊成形术后并发症的累计发生率、相关预测因素，以及其在不同患者人群中的发生情况。我们通过数字数据库检索与经皮二尖瓣球囊成形术并发症相关的研究，并采用医学主题词（Medical Subject Heading, MeSH）关键词筛选获取相关文献。最终共纳入37篇文献（其中随机对照试验8篇、非随机临床试验7篇、观察性研究22篇）进行定性分析。37项研究共计纳入11803例行经皮二尖瓣球囊成形术的患者，手术平均成功率为84.54%。最常见的并发症为二尖瓣反流（发生率8.2%），其次为房间隔缺损（发生率2.4%）。其余相关并发症如脑卒中、心包填塞、二尖瓣瓣叶破裂及传导异常的占比均低于1%。