PHARMACOLOGICAL ADVANCES IN TARGETED DRUG DELIVERY SYSTEMS

Targeted drug delivery systems (TDDS) represent a major advancement in modern pharmacology, aiming to improve therapeutic efficacy while minimizing systemic toxicity. This theoretical review explores recent developments in nanocarriers, liposomes, polymer-based systems, and ligand-targeted therapies. The study highlights mechanisms of targeted delivery, clinical applications in oncology and chronic diseases, and pharmacokinetic advantages over conventional drug administration. Findings indicate that TDDS significantly enhances drug bioavailability, reduces adverse effects, and improves treatment precision. However, challenges such as high production costs, stability issues, and regulatory limitations remain barriers to widespread clinical application.

靶向给药系统（Targeted drug delivery systems, TDDS）是现代药理学领域的重大进展，其旨在提升治疗疗效的同时，最大限度降低全身毒性。本理论综述探讨了纳米载体、脂质体、聚合物载体系统及配体靶向疗法的最新研究进展，重点阐述了靶向递送的作用机制、在肿瘤学与慢性病领域的临床应用，以及相较于常规给药方式所具备的药代动力学优势。研究结果表明，TDDS可显著提升药物生物利用度、降低不良反应并优化治疗精准度。然而，生产成本高昂、稳定性问题以及监管限制等挑战，仍是制约其广泛临床应用的障碍。