Data_Sheet_1_Exposure therapy tailored to inhibitory learning principles in a naturalistic setting: an open pilot trial in obsessive-compulsive outpatient care.PDF

Inhibitory learning (IL) theory offers promising therapeutic strategies. However, more evidence is needed, especially regarding OCD treatment in routine care. The present pilot study investigated the positive and negative effects of IL-focused cognitive-behavioral therapy (CBT) in a university outpatient setting. A total of N = 21 patients (57.14% male, mean age 31.14, SD = 12.39 years) passed through manualized therapy delivered by licensed psychotherapists. Between the first and 20th IL-focused CBT session, obsessive-compulsive symptoms (Obsessive Compulsive Inventory-Revised, d = 3.71), obsessive beliefs (Obsessive-Beliefs Questionnaire, d = 1.17), depressive symptoms (Beck Depression Inventory, d = 3.49), and overall psychological distress (Global Severity Index, d = 3.40) decreased significantly (all ps < 0.01). However, individual patients reported some negative effects of therapy. The results underline the value of thorough investigations of novel therapeutic interventions in naturalistic settings.

抑制学习（Inhibitory Learning, IL）理论为临床治疗提供了极具潜力的策略。然而目前仍需更多相关证据，尤其是针对常规诊疗中的强迫症（Obsessive-Compulsive Disorder, OCD）治疗场景。本项先导性研究于某高校门诊环境中，探究了聚焦抑制学习的认知行为疗法（Cognitive Behavioral Therapy, CBT）的正负向疗效。共计21名患者参与研究（其中男性占比57.14%，平均年龄31.14岁，标准差（Standard Deviation, SD）=12.39岁），所有受试者均接受由持证心理治疗师实施的标准化手册化治疗。在第1至第20次聚焦抑制学习的认知行为疗法疗程期间，受试者的强迫症症状（修订版强迫症量表（Obsessive Compulsive Inventory-Revised），d=3.71）、强迫信念（强迫信念问卷（Obsessive-Beliefs Questionnaire），d=1.17）、抑郁症状（贝克抑郁量表（Beck Depression Inventory），d=3.49）以及整体心理痛苦水平（整体严重程度指数（Global Severity Index），d=3.40）均出现显著下降（所有p值均<0.01）。不过，部分个体受试者报告了治疗带来的不良影响。本研究结果凸显了在自然主义诊疗场景中对新型治疗干预手段开展系统性深入研究的重要价值。