A proteomic approach to understand the clinical significance of acute myeloid leukemia-derived extracellular vesicles reflecting essential characteristics of leukemia

Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and its overall incidence has been increasing gradually over the years. Extracellular vesicles (EVs) are known to express the properties of their parental cells, including proteins, RNAs, and DNAs. As EVs are representative of their parental tissues, they are excellent tools for understanding how cancer cells adapt to their environment. Proteomic analysis is a useful technique in cancer research that can be both quantitative and qualitative when determining the interrelationships between proteins in cells. It is clinically important to identify novel differentially expressed proteins (DEPs) from EVs in AML that could be used as biomarkers

急性髓系白血病（Acute myeloid leukemia, AML）是成人最常见的急性白血病类型，其整体发病率呈逐年递增趋势。已知细胞外囊泡（extracellular vesicles, EVs）可携带来自其亲本细胞的特性，涵盖蛋白质、RNA及DNA。由于细胞外囊泡能够反映其来源组织的特征，因此成为解析癌细胞如何适应所处微环境的理想研究工具。蛋白质组学分析是癌症研究领域的实用技术，在解析细胞内蛋白质间的相互关联时，可同时实现定性与定量检测。从急性髓系白血病患者的细胞外囊泡中筛选可作为生物标志物的新型差异表达蛋白（differentially expressed proteins, DEPs），具备重要的临床价值。