Context-dependent IL-1 mRNA-destabilization by TTP prevents dysregulation of immune homeostasis

We report that TTP exhibits context-dependent target destabilisation and that such context-defined mRNA decay is essential for maintaining steady state IL-1 levels in the physiological range mRNA profiles of untreated and LPS-stimulated WT and TTP-/- murine bone marrow-derived dendritic cells

我们在此报道，TTP（Tristetraprolin）可介导依赖于上下文的靶标去稳定化作用，且此类依赖于上下文的mRNA降解过程对于将IL-1的稳态水平维持在生理范围内至关重要。本数据集涵盖未经处理及脂多糖（Lipopolysaccharide, LPS）刺激的野生型（Wild Type, WT）与TTP基因敲除（TTP-/-）小鼠骨髓来源树突状细胞的mRNA转录组谱。