Top genome-wide association results for IL-6, ESR, MCP-1, and hsCRP.

The table summarizes top genome-wide association signals for IL-6, ESR, MCP-1 and hsCRP phenotypes in the HapMap based GWAS (Step 1), as well as results in the replication independent cohort (Step 2) and in the combined data-sets. For each marker, frequency and effect estimates are given with respect to the minor allele. Imputation quality scores (RSQ) are reported for imputed SNPs. Novel signals are indicated in bold.
aThe effect size is measured in standard deviation units, being estimated as the β coefficient of the regression model when using the normalized trait (e.g. an effect size of 1.0 implies each additional copy of the allele being evaluated increases trait values by 1.0 standard deviations).
bIndependent signals.

本表格总结了基于国际人类基因组单体型图计划（HapMap）的全基因组关联研究（GWAS，Step 1）中针对白细胞介素6（IL-6）、红细胞沉降率（ESR）、单核细胞趋化蛋白1（MCP-1）及高敏C反应蛋白（hsCRP）表型的全基因组显著关联信号，同时纳入独立验证队列（Step 2）及合并数据集的分析结果。针对每个遗传标记，均给出了以次要等位基因为参照的等位基因频率与效应估计值。基因型填充后的单核苷酸多态性（Single Nucleotide Polymorphism，SNPs）的填充质量评分（RSQ）已一并报告，新发现的关联信号以加粗字体标注。
a 效应量以标准差单位衡量，在对表型进行标准化处理后，通过回归模型的β系数进行估计（例如，效应量为1.0意味着所评估的等位基因每额外增加一个拷贝，表型值将提升1.0个标准差）。
b 独立关联信号。