Differential expression of plasma exosomal microRNA in severe acute pancreatitis

The incidence rate of acute pancreatitis is increasing, and severe acute pancreatitis (SAP) is associated with a high mortality rate, which may be reduced by a deeper understanding of its pathogenesis. In addition, an early determination of the severity of acute pancreatitis remains challenging. The aim of this study was to identify potential biomarkers for early identification and monitoring of acute pancreatitis and to shed light on the underlying pathogenic mechanisms of SAP. The expression levels of plasma exosomal microRNA (miRNA) in patients with pancreatitis have been associated with the disease. Thus, this study compared the expression levels of exosomal miRNA in plasma collected from four patients with SAP and from four healthy participants.

急性胰腺炎（acute pancreatitis）的发病率呈逐年上升趋势，重症急性胰腺炎（severe acute pancreatitis，SAP）的病死率居高不下，对其发病机制的深入解析或可降低该疾病的死亡率。此外，早期精准评估急性胰腺炎的严重程度仍存在较大挑战。本研究旨在筛选可用于急性胰腺炎早期识别与病情监测的潜在生物标志物，并阐明重症急性胰腺炎潜在的发病机制。胰腺炎患者血浆外泌体微小RNA（microRNA，miRNA）的表达水平与该疾病密切相关。基于此，本研究采集了4例重症急性胰腺炎患者与4例健康受试者的血浆样本，对比分析两组血浆中外泌体miRNA的表达水平。