Next Generation Sequencing Analysis of Wild Type and SRSF2-MKO Skeletal Muscle Transcriptomes

We report skeletal muscle developmental defects in SRSF2 MyoD-Cre mice, in which SRSF2 is ablated in skeletal muscle. The control and SRSF2 MyoD-Cre gene in hindlimbs mRNA profiles were generated by deep sequencing, using HiSeq 2500 instrument.本研究报道了SRSF2 MyoD-Cre小鼠的骨骼肌发育缺陷表型，该模型中SRSF2基因在骨骼肌组织中被特异性敲除。本研究采用HiSeq 2500测序仪，通过深度测序技术获取了对照组与SRSF2 MyoD-Cre小鼠后肢组织的mRNA转录组谱。