Data underlying the publication 'Uptake and toxicity of polystyrene micro/nanoplastics in gastric cells: Effects of particle size and surface functionalization'

This dataset is for figures in the paper entitled 'Uptake and toxicity of polystyrene mico/nanoplastics in gastric cells: Effects of particle size and surface functionalization'. The objective of the study was to determine if toxicity of polystyrene nanoplastics/microplastics in human gastric cells is dependent on particle size, surface functionalization, dose and exposure period. For the study, polystyrene particles of sizes 50 - 5000 nm with amine, carboxyl or no surface functionalization were used. Human gastric SNU-1 cells were treated with the particles for 4 or 24 h and toxicity of the particles was measured using various assays. Smaller particles (50 nm) were found to be most toxic to the cells, irrespective of surface functionalization. Positive surface charge (amine surface functionalization) increased acute toxicity in the cells.

本数据集用于支撑题为《胃细胞中聚苯乙烯微/纳米塑料（polystyrene micro/nanoplastics）的摄取与毒性：粒径与表面官能化（surface functionalization）的影响》的论文中的相关图表。本研究旨在探究人胃细胞内聚苯乙烯微/纳米塑料的毒性是否取决于粒径、表面官能化程度、暴露剂量与暴露时长。本次实验使用了粒径范围为50~5000 nm，分别带有氨基（amine）、羧基（carboxyl）修饰或未进行表面官能化的聚苯乙烯颗粒。将人胃黏膜SNU-1细胞（SNU-1 cells）与上述颗粒共孵育4小时或24小时，并通过多种检测分析法（assays）测定颗粒的细胞毒性。实验结果显示，无论表面官能化类型如何，粒径为50 nm的颗粒对细胞的毒性最强。表面带正电荷的氨基修饰（amine surface functionalization）可增强细胞的急性毒性。