Table_1_Multi-Omics Analysis in Initiation and Progression of Meningiomas: From Pathogenesis to Diagnosis.XLSX

Meningiomas are common intracranial tumors that can be cured by surgical resection in most cases. However, the most disconcerting is high-grade meningiomas, which frequently recur despite initial successful treatment, eventually conferring poor prognosis. Therefore, the early diagnosis and classification of meningioma is necessary for the subsequent intervention and an improved prognosis. A growing body of evidence demonstrates the potential of multi-omics study (including genomics, transcriptomics, epigenomics, proteomics) for meningioma diagnosis and mechanistic links to potential pathological mechanism. This thesis addresses a neglected aspect of recent advances in the field of meningiomas at multiple omics levels, highlighting that the integration of multi-omics can reveal the mechanism of meningiomas, which provides a timely and necessary scientific basis for the treatment of meningiomas.

脑膜瘤（Meningiomas）是一类常见的颅内肿瘤，多数病例可通过手术切除实现治愈。然而，最为棘手的当属高级别脑膜瘤：即便初始治疗取得成功，这类肿瘤仍常出现复发，最终导致患者预后不佳。因此，对脑膜瘤进行早期诊断与分型，对后续干预治疗及改善患者预后至关重要。越来越多的研究证据表明，多组学研究（multi-omics study，包含基因组学、转录组学、表观基因组学、蛋白质组学）有望应用于脑膜瘤诊断，且可揭示其与潜在病理机制之间的内在关联。本论文聚焦于当前脑膜瘤领域多组学层面研究进展中被忽视的方向，着重指出多组学整合分析可揭示脑膜瘤的发病机制，这为脑膜瘤的临床治疗提供了及时且必要的科学依据。