Effect of a dendritic cells derived extracellular vesicle as therapeutic vaccine platform to induce neuroprotective immunity for spinal cord injury. Effect of a dendritic cells derived extracellular vesicle as therapeutic vaccine platform to induce neuroprotective immunity for spinal cord injury

we designed a nano-vaccine platform using dendritic cell-derived small extracellular vesicles (DsEVs) as carriers for MBP87-99A91(A91-DsEVs) to induce a neuroprotective immunity for spinal cord injury. Overall design: We performed gene expression profilling analysis using data obtained from RNA-seq of A91-DsEVs treatment group and control group (PBS group) at 3 time points, there were 4 samples in A91-DsEVs treatment group in each time point, and 3 samples in PBS group at each time point

本研究设计了一种纳米疫苗平台，以树突状细胞来源的小型细胞外囊泡（dendritic cell-derived small extracellular vesicles, DsEVs）作为MBP87-99A91的递送载体（即A91-DsEVs），用于诱导针对脊髓损伤的神经保护性免疫。总体实验设计：本研究针对A91-DsEVs处理组与对照组（磷酸盐缓冲液（PBS）组）三个时间点的样本开展基因表达谱分析，分析所用数据来源于两组样本的RNA测序（RNA-seq）结果；每个时间点的A91-DsEVs处理组包含4份样本，PBS组每个时间点包含3份样本。