Nuclear Receptor Corepressors are Required for the Histone Deacetylase Activity of HDAC3 In Vivo (ChIP-Seq). Mus musculus

We report the genomic regions enriched in Histone Deacetylase 3 (HDAC3) in mouse livers. We also report the change of HDAC3 occupancy upon DAD mutations in NCOR and SMRT. Overall design: HDAC3 enriched genomic regions in WT and NS-DADm mice livers using Illumina GAIIx.

本研究报道了小鼠肝脏中组蛋白去乙酰化酶3（Histone Deacetylase 3，HDAC3）富集的基因组区域，同时报道了NCOR与SMRT的DAD突变后HDAC3结合占有率的变化情况。实验设计概况：采用Illumina GAIIx测序平台，对野生型（Wild Type，WT）与NS-DADm小鼠的肝脏组织中富集HDAC3的基因组区域开展测序分析。