Data_Sheet_1_Clinical validity of IntelliSpace Cognition digital assessment platform in mild cognitive impairment.PDF

We evaluated a digital cognitive assessment platform, Philips IntelliSpace Cognition, in a case-control study of patients diagnosed with mild cognitive impairment (MCI) and cognitively normal (CN) older adults. Performance on individual neuropsychological tests, cognitive z-scores, and Alzheimer's disease (AD)-specific composite scores was compared between the CN and MCI groups. These groups were matched for age, sex, and education. Performance on all but two neuropsychological tests was worse in the MCI group. After ranking the cognitive scores by effect size, we found that the memory score was the most impaired, followed by executive functioning. The Early AD/MCI Alzheimer's Cognitive Composite (EMACC) and Preclinical Alzheimer's Cognitive Composite (PACC) scores were constructed from the digital tests on Philips IntelliSpace Cognition. Both AD-specific composite scores showed greater sensitivity and specificity than the Mini-Mental State Examination or individual cognitive z-scores. Together, these results demonstrate the diagnostic value of Philips IntelliSpace Cognition in patients with MCI.

本研究针对确诊为轻度认知障碍（mild cognitive impairment, MCI）与认知正常（cognitively normal, CN）的老年群体开展病例对照研究，对数字认知评估平台飞利浦IntelliSpace认知系统（Philips IntelliSpace Cognition）进行了评估。研究对比了CN组与MCI组在各项神经心理学测试、认知Z分数以及阿尔茨海默病（Alzheimer's disease, AD）专属复合评分中的表现。两组受试者在年龄、性别与受教育程度上进行了匹配。MCI组在除两项测试外的所有神经心理学测试中表现均更差。按效应量对认知评分进行排序后，结果显示记忆评分受损程度最为严重，其次为执行功能。基于飞利浦IntelliSpace认知系统的数字测试任务，我们构建了早期AD/MCI阿尔茨海默认知复合评分（Early AD/MCI Alzheimer's Cognitive Composite, EMACC）与临床前阿尔茨海默认知复合评分（Preclinical Alzheimer's Cognitive Composite, PACC）。相较于简易精神状态检查表（Mini-Mental State Examination），这两项AD专属复合评分均展现出更优的灵敏度与特异度，其诊断性能亦优于单项认知Z分数。综上，上述结果证实了飞利浦IntelliSpace认知系统在轻度认知障碍患者中的诊断价值。